Diseases and Conditions

Mild cognitive impairment (MCI)

Risk factors

The strongest risk factors for MCI are:

  • Increasing age
  • Having a specific form of a gene known as APOE e4, also linked to Alzheimer's disease — though having the gene doesn't guarantee that you'll experience cognitive decline

Other medical conditions and lifestyle factors have been linked to an increased risk of cognitive change, including:

  • Diabetes
  • Smoking
  • High blood pressure
  • Elevated cholesterol
  • Obesity
  • Depression
  • Lack of physical exercise
  • Low education level
  • Infrequent participation in mentally or socially stimulating activities